李晓晓，博士，珠海科技学院生命科学学院教师。本科毕业于河南中医药大学药学院中药学专业，硕士毕业于暨南大学药学院药理学专业，博士毕业于香港理工大学应用生物与化学科技系。先后在香港中文大学和中山大学附属第五医院从事博士后研究工作。主要研究方向包括代谢相关性疾病的发病机理、免疫失调与抑郁症等。主持香港理工大学RAP启动项目1项，深圳市科技创新委面上项目1项。以第一作者或通讯作者发表SCI学术论文10篇。

科研方向：

代谢相关性疾病的发病机理、免疫失调与抑郁症等。

代表性文章：

         1.Jia-Yi Zheng#, Rui-Kang Pang#, Jiang-Hong Ye, Shan Su, Jia Shi, Yu-Hui Qiu, Hua-Feng Pan, Ru-Yu Zheng, Xin-Rui Hu, Qi-Wen Deng, Xiao-Xiao Li*, Ye-Feng Cai*, Shi-Jie Zhang*. Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway. Phytomedicine. 2024 Dec;135:156248.

         2. Shan Su#, Ting Liu#, Jia-Yi Zheng, Hai-Cui Wu, Vincent W. Keng*, Shi-Jie Zhang* and Xiao-Xiao Li*. Huang Lian Jie Du decoction attenuated colitis via suppressing macrophage Csf1r/Src pathway and modulating gut microbiota. Frontiers in Immunology. 2024 Sep 26.

        3. Zheng JY^#, Li XX^#, Lin WY, Su S, Wu HC, Hu RD, Pan HF, Ye JH, Cai YF, Zhang SJ. Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway. J Ethnopharmacol. 2023 Oct 28;315:116658.

        4. Li XX^#, Chen SG^#, Yue GG, Kwok HF, Lee JK, Zheng T, Shaw PC, Simmonds MSJ, Lau CB. Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice. Phytomedicine. 2021 Sep;90:153625.

        5. Li XX^#, Lu XY^#, Zhang SJ, Chiu AP, Lo LH, Largaespada DA, Chen QB, Keng VW. Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomed Pharmacother. 2019 Mar;111:68-75.

        6. Li XX, Zhang SJ, Chiu AP, Lo LH, Huang J, Rowlands DK, Wang J, Keng VW. Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor. Cancer Med. 2018 Sep;7(9):4791-4800.

        7. Li XX^#, Zhang SJ^#, Man KY, Chiu AP, Lo LH, To JC, Chiu CH, Chan CO, Mok DKW, Rowlands DK, Keng VW. Schwann cell-specific Pten inactivation reveals essential role of the sympathetic nervous system activity in adipose tissue development. Biochem Biophys Res Commun. 2020 Oct 15;531(2):118-124.

        8. Zhang SJ^#, Li XX^#, Yu Y, Chiu AP, Lo LH, To JC, Rowlands DK, Keng VW. Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy. Biochem Biophys Res Commun. 2019 Jul 12;515(1):50-56.

        9. Li XX^#, Zhang SJ^#, Chiu AP, Lo LH, To JC, Cui HN, Rowlands DK, Keng VW. Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. G3 (Bethesda). 2019 Jan 9;9(1):297-303.

        10. Li XX, Tsoi B, Li YF, Kurihara H, He RR. Cardiolipin and its different properties in mitophagy and apoptosis. J Histochem Cytochem. 2015 May;63(5):301-11. doi: 10.1369/0022155415574818. Epub 2015 Feb 11. PMID: 25673287; PMCID: PMC4409943.