李晓晓，博士，珠海科技学院生命科学学院教师，中药学系主任。博士毕业于香港理工大学应用生物与化学科技系，师从Dr. Vincent Keng教授。随后分别于香港中文大学李達三葉耀珍中醫藥研究發展中心及中山大学附属第五医院从事博士后研究工作。主要研究方向包括代谢相关性疾病的发病机制与干预策略，以及免疫失调在抑郁症发病中的作用。主持香港理工大学RAP启动项目1项、深圳市科技创新委面上项目1项；获授权国家发明专利1项；以第一作者或通讯作者身份发表SCI收录学术论文14篇。

研究方向：

1. 代谢相关性疾病的发病机制及干预策略研究；

2. 免疫失调与抑郁症的关联机制研究。

代表性论文：

1. Rui-Kang Pang, Jia-Yi Zheng, Hao-You Xu, Yuan-Qi Zhao, Shan Su, Kai Le, Ye-Feng Cai*, Shi-Jie Zhang* and Xiao-Xiao Li*. Microglia specific Csf1r haploinsufficiency induces depressive-like behaviors by promoting NLRP6/caspase-1 signaling in mice. Brain Behav Immun. 2025 Apr 17;128:383-399. PMID: 40252935.（中科院一区）

2. Vincent W. Keng*, Shan Su, Elyse S.T. Chui, Jeffrey C. To, Yao-jun Zhang & Xiao-Xiao Li*. ANKRD17 induces pro-survival signaling pathways that enhances cellular invasion and migration during hepatocellular carcinoma tumorigenesis. iScience.17 Apr 2025, 28(5)（中科院三区）

3. Rui-Kang Pang#, Xiang-Yu Peng#, Jia Shi#, Shan Su, Jia-Yi Zheng, Kai Le, Vincent W. Keng*, Shi-Jie Zhang* and Xiao-Xiao Li*. Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway. Chinese Medicine. 2025 Apr 15;20(1):50.（中科院一区）

4. Li HD#, Zheng JY#, Tan KW, Su JX, Chen W, Pang RK, Wu GL, Qiu YH, Li XX*, Cai YF*, Zhang SJ*. Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro. Int Immunopharmacol. 2025 Mar 17;153:114461.(中科院二区）

5. Jia-Yi Zheng#, Rui-Kang Pang#, Jiang-Hong Ye, Shan Su, Jia Shi, Yu-Hui Qiu, Hua-Feng Pan, Ru-Yu Zheng, Xin-Rui Hu, Qi-Wen Deng, Xiao-Xiao Li*, Ye-Feng Cai*, Shi-Jie Zhang*. Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway. Phytomedicine. 2024 Dec;135:156248. (中科院一区）

6. Shan Su#, Ting Liu#, Jia-Yi Zheng, Hai-Cui Wu, Vincent W. Keng*, Shi-Jie Zhang* and Xiao-Xiao Li*. Huang Lian Jie Du decoction attenuated colitis via suppressing macrophage Csf1r/Src pathway and modulating gut microbiota. Front Immunol. 2024 Sep 26;15:1375781.(中科院二区）

7. Zheng JY#, Li XX#, Lin WY, Su S, Wu HC, Hu RD, Pan HF, Ye JH, Cai YF, Zhang SJ. Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway. J Ethnopharmacol. 2023 Oct 28;315:116658. (中科院二区）

8. Li XX#, Chen SG#, Yue GG, Kwok HF, Lee JK, Zheng T, Shaw PC, Simmonds MSJ, Lau CB. Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice. Phytomedicine. 2021 Sep;90:153625. (中科院一区）

9. Li XX#, Lu XY#, Zhang SJ, Chiu AP, Lo LH, Largaespada DA, Chen QB, Keng VW. Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomed Pharmacother. 2019 Mar;111:68-75. (中科院二区）

10. Li XX, Zhang SJ, Chiu AP, Lo LH, Huang J, Rowlands DK, Wang J, Keng VW. Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor. Cancer Med. 2018 Sep;7(9):4791-4800. (中科院三区）