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袁宁宁

发布时间:2024/12/09    浏览次数:10
初审: 复审: 终审:

 

博士。博士毕业于南方医科大学中药学专业,现为珠海科技学院生命科学学院中药学专业专任教师。主要从事中医药防治代谢类疾病的基础与临床研究,通过高通量技术筛选中药的有效成分并探索干预疾病的新靶标。在此领域已发表多篇国际学术论文,近五年以第一作者身份发表SCI论文6篇。参与多项科研基金,其中国家自然科学基金3项。

教学工作(所授课程):体内药物分析

科研方向:主要从事中医药防治代谢类疾病的基础与临床研究。长期致力于通过高通量技术手段筛选中药的有效成分,探索其在代谢类疾病干预中的新靶标与作用机制。研究方向涵盖了中药复方、单味药在糖尿病、肥胖、脂肪肝等代谢综合征中的应用,特别关注如何利用中药的多靶点、多途径作用优势,提供个性化的预防与治疗策略。

主持科研项目:

1.自噬对记忆和突触可塑性的调控作用和分子机制研究(31871024),国家自然科学基金委员会,面上项目,2019.01-2022.12,59万元,参与人。

2.肾康丸通过AURKB/RacGAP1调控RhoA信号网络治疗糖尿病肾病的作用机制(8217151811),国家自然科学基金委员会,面上项目,2022.01-2025.12,70万元,负责人。

3.Baf60c-Trib3依赖调控及其基因多态在2型糖尿病血管内皮功能损伤中的作用及机制(81903715),国家自然科学基金青年科学基金项目,2020.01-2022.12,21万元,参与人。

代表性论文:

1. Ning-Ning Yuan*; Jianxin Diao; Jiamei Dong, et al. Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist. Biomedicine & Pharmacotherapy, 2024, 171: 116208.

2. Ning-Ning Yuan*; Cui-Zan Cai; Ming-Yue Wu, et al. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology. Frontiers in Pharmacology, 2019, 10.

3. Ning-Ning Yuan*; Cui-Zan Cai; Ming-Yue Wu, et al. Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies. BMC Complementary and Alternative Medicine, 2019, 19(1): 109.

4. Ning-Ning Yuan*; Yuchi Chen; Yangtian Yan, et al. Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-κB/snail axis in diabetic nephropathy based on network pharmacology analysis. Heliyon, 2024, 10(16).

5. Yangtian Yan; Ning-Ning Yuan*; Yuchi Chen, et al. SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation. Chinese Medicine, 2024, 19(1). (Co-first author)

6. Jia-Mei Dong; Rui-Qi Wang; Ning-Ning Yuan* , et al. Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma. Frontiers in Cell and Developmental Biology, 2023, 11. (Co-first author)