博士毕业于哈尔滨工业大学生物医学工程专业，后于澳门大学中华医药研究所从事博士后研究。现为珠海科技学院生命科学学院专任教师。参与科研项目3项。累计发表学术论文15篇，其中第一作者/通讯作者发表SCI论文8篇，影响因子>10分四篇，中文核心期刊论文2篇。

研究方向：聚焦肿瘤纳米免疫治疗与肿瘤免疫微环境重塑：开发肿瘤微环境响应性智能纳米递送系统（pH/GSH/ROS/酶等），协同诱导铜死亡、铁死亡等新型细胞死亡以增强免疫原性并克服免疫逃逸；结合代谢调控（如胆固醇）、自噬干预及免疫检查点调节促进“冷肿瘤”向“热肿瘤”转化，并采用单细胞测序等高维免疫分析解析作用机制；探索中药活性成分与CRISPR等技术在纳米医学中的交叉转化应用。

代表性论文：

1.Enze Li, Nan Wang, Peng Hua, et al. Self-reinforced dual-cascade nanoreactor enhancing ferroptosis and improving immune microenvironment for cancer chemo-immunotherapy. Acta Pharmaceutica Sinica B. 2025.

2.Enze Li, Liewei Wen, Caiyun Yin, et al. Copper ionophore-autophagy interference nanoregulators for tumor self-defense reprograming to amplify cuproptotic stress and antitumor immunity. Journal of Controlled Release. 2025.

3.Yi Sun#, Enze Li^#, Wenzhao Zhong, et al. GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma. Mater Today Bio. 2025.

4.Yi Sun, Guixiang Lv, Enze Li^*. Thermosensitive hydrogel delivering a self-reinforced dual cascade nanoreactor for synergistic cuproptosis induction and immune microenvironment remodeling. Chemical Engineering Journal. 2025.

5.Enze Li, Yi Sun, Guixiang Lv, et al. Involvement of hydrogen peroxide in sonodynamical effect with sinoporphyrin sodium in hypoxic situation. Free Radic Res. 2021.

6.Enze Li, Yi Sun, Guixiang Lv, et al. Sinoporphyrin sodium mediated sonodynamic therapy generates superoxide anion under hypoxia environment. New Journal of Chemistry. 2021.

7.Enze Li, Yi Sun, Guixiang Lv, et al. The Abnormal Physicochemical Phenomena of Singlet Oxygen Sensor Green in Water in the Presence of Ultrasound. Chemistryselect. 2021.